An Upper Mustang itinerary typically involves flying to Jomsom from Pokhara, then trekking or driving through ancient villages like Kagbeni, Chhusang, Syangboche, Ghami, and Tsarang to reach the walled city of Lo Manthang, the cultural heart, with exploration days in Lo Manthang and nearby Choser Caves, before returning via a similar route, often involving local flights/drives back to Pokhara and then Kathmandu, usually spanning 12-16 days to cover the unique high-desert landscape, Tibetan culture, monasteries, and stunning scenery.